Sorry for your refusal.
This is uncanny! Second refusal of the day based on incorrect selection of the same NOC. You should've chosen NOC 0124/0621 for a generic sales/retail role rather than 6221. Look at your job responsibilities closely once again and choose the appropriate NOC. There is no point in asking for reassessment here. Create a fresh EE profile and get back into the pool.
I'm sure it is painful - I had a rejection on a silly technicality after waiting for 4 months and this must hurt even more than that did as it comes much later in the process. But you'll have to shrug it off and move ahead with life. Spend time with friends over the weekend and get this refusal out of your system so that you can start afresh on Monday.
Hang in there and All the best!