both applications need to be submitted in canada by the sponsor. for outland application, the sponsorship evaluation is done in canada first (takes around a month) and then the documents are sent over to the local office for evaluating the dependent. for inland, the whole processing is done in canada.
if you have an open file in London, you may be receiving instructions at your local address in UK from the visa office. they may ask you to submit your passport along with PCC, medical reports from london.
you can check here for details
http://www.cic.gc.ca/english/immigrate/sponsor/spouse-apply-how.asp