1. Ontario is a province not a state
2. from what you are describing you did not receive nomination, just NOI (notification of interest) from Ontario and for some reason your were too late to decide to use it - lesson to be learned there are always more NOI than nominations.
3. You cannot send any active EOI to Ontario. When they send their NOI, they will check which profiles do meet all their criteria (being interested to reside in Ontario or in provinces and territories; at least 3 years bachelor diploma, at least 1 year of work experience within last 5 years, CBL 7 from one of the official languages and for HCP you also need to have at least 400 points.
4. The way to "refresh" your profile is to deactivate the old one and to recreate a new one and activate it.
5. One thing that was not confirmed until now is, if Ontario will send another NOI to the applicant that did not use up the previous NOI (it is not known if they have a database of old NOI linked to accounts or not).