Go ahead and apply...... There is NO medical inadmissibility for HIV + these days. Me and several +ve guys have got their PR since May 2018 ....If your wife is on (any) medication for more than a year and Undetectable, she will 100% clear the medicals
There are several provinces which give HIV medicines for free... eg British Columbia, Alberta, Nova Scotia, PEI, New Brunswick & Newfoundland. There are few threads in the forum about the Positive immigrants and Would be glad to help you about the medical exams and the process....Best of luck