I have played Plague Inc and there are two rules to a successful pandemic (Hehe):You know what I am really REALLY REALLY worried about?
Someone in middle east getting infected with omnicorn (which .... is going to be endemic soon) and then getting MERS from a camel. Both diseases happen from coronaviruses and coronaviruses can undergo recombination. IF MERS and Omicron undergo recombination to yield a super infective and super lethal (30% fatality) coronavirus.... We are done for.
1. You cannot have high severity when you have not infected enough people. There will be too much scrutiny and the virus will be rooted out. All the severe viruses like Ebola, Nipah were rooted out as soon as they sprung up because of its severity. COVID goes under the radar frustratingly for precisely the reason that it looks like the common cold for 95% of the people.
2. Madagascar. You have to infect and terminate Madagascar early on. The virus will always lose otherwise.