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I have come across many success stories where people passed the medical with Stage 2 CKD i.e >60 eGFR. In your case don't know the stage she is currently in with what eGFR and ACR etc. Moreover at first how did the genetic disease was diagnosed at first level. It would be beneficial to share this information to access the situation rightly.
 
It's hard for any of us to really answer that. It will depend on how IRCC has assessed her medical condition. If you get a PFL, then my recommendation will be to hire an immigration lawyer to help you with the response.
Hello scylla from which office does the PFL comes. Is it Niagara office or the local office that I submitted??? Please help me if you can
 
Hello scylla from which office does the PFL comes. Is it Niagara office or the local office that I submitted??? Please help me if you can

Normally it would come from the office that currently has your application.
 
Dear Mohammad, did you got any update, do not find any response after Feb 2024, plz advise