Actually, I am not entirely sure on this but I know many trusted and senior members of this forum believe it does not. I myself only ordered twice, once after medicals passed and then second time after I got the result of the first one (because it said review required). Then, when I got the result for the second ordered GCMS, I found out, a11.2 has passed and application is approved.
What's worth noting is that my application was actually approved on 30th April itself. They sent PPR on June 16th.