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Just asking if there has been any instance that the SOWP of an international student been refused even if the SP is approved?

Yes, there are many instances of this happening. Study permit approval does not guarantee SOWP approval.
 
Thank you! Just a follow up question, when they review SOWP extension application of an international student's spouse, do they require that the SOWP holder should be employed in an in-demand skill? Or does not matter at all?