This is the link the describes where to send all applications:
http://www.cic.gc.ca/english/information/offices/apply-where.asp#u
You'll submit your application to Buffalo, NY. Here is the mailing address, etc.:
http://www.cic.gc.ca/english/information/offices/missions/buffalo.asp
Get the Buffalo-specific instructions here:
http://www.cic.gc.ca/english/immigrate/skilled/application-regular.asp#visa_offices
Information on U.S. dollar fees can be found at this website:
http://geo.international.gc.ca/can-am/buffalo/visas/fees-en.asp
You cannot use the simplified application process for Buffalo, and you don't have a choice of sending your application to a different office. Therefore, you must use the regular process.