It would not affect your landing. Reading through your mail it seems there is an issue between the principal applicant and the spouse. This has to be managed well so as not to cause delays in the application processing. My advise is not to write to Accra but to just carry on with the application. At the point of visa issuance ensure the other party agrees to submit his/her passport for visa issuance otherwise it will raise a red flag.
If visa is issued to every member of the family, the principal applicant and others should proceed to land except the dissenting spouse. All the principal applicant would say is that the spouse will be joining later. But the challenge there is how to manage the not-interested spouse from causing trouble if kids are travelling with the principal applicant.
I have read a couple of stories of where one of the spouse wasn't interested in the immigration project only for them to have a change of mind latter. Please manage this process careful so as not jeopardise the whole family chances.
Regards and happy Sunday all