computergeek
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True. I don't usually point out that the Positive Predictive Value (PPV) of the test is actually low in a low prevalence population, but that is in fact the case. Ideally, you would be best served by having a co-culture test done for confirmation, but I only know one lab that performs the test (in New York). Repeating the same test can eliminate laboratory error, but does not actually improve the PPV of the test (because the tests are self-referenced. Namely, they prove the sensitivity of new tests by validating against the results of older tests). That's a rather technical argument and one I certainly wouldn't try to present to CIC, as I suspect it would go over their heads.on-hold said:Just to emphasize something that was said up above -- if you have not done this, your wife needs to be retested. The usefulness of the test is not its sensitivity, which is very high, but the combination of its sensitivity and the prevalence of HIV. False positives are known. You should also be retested, although your negative test is more likely to be correct.
This is ingrained in the CIC system as well. These days a finding HIV positivity is very difficult to overcome precisely because they assume that a patient will be compliant - and thus the rejection is on the grounds of excessive demand. The prices of medication are propped up in Canada and further reinforced by the Schedule F prohibition against importation of generic equivalents (so an individual cannot import low cost equivalents from other jurisdictions where medications have lost patent status). Even the US no longer tests for HIV as part of immigration screening - but CIC does. Last I looked, less than 1/3 of non-EDE applicants who tested HIV positive were granted permanent residency on the basis of excessive demand.on-hold said:Other than that, keep going as you are -- I work in public health and HIV prevention , and would like to emphasize that the public perception of HIV has not changed in the last 20 years, even though the medical state of knowledge has. HIV today is a chronic, manageable infection, and if your wife is treated, complies with her doctor and testing regime, and takes care of herself, she can expect to lose about 5 years of life (on average). By comparison, if you smoke, you will lose 13 life years (on average). The fear and stigma associated with HIV are out of proportion for disease that is quite comparable to Hepatitis B.
If you qualify, there is one treatment regimen that does not exceed the excessive demand threshold when purchased in Canada because the cost is below the cut-off amount. That is 3TC, ZDV and NVP (Lamivudine, Zidovudine, and Nevirapine). They are all off-patent in Canada (but Combivir, which combines 3TC and ZDV is not off patent yet, so the cost is proportionately higher. This is an alternative first line treatment, but most patients generally don't qualify for this treatment based upon current treatment guidelines (specifically, the requirements for a low CD4 count prior to starting NVP). Over the next several years additional drugs will come off-patent and become viable alternatives. They trade cost against convenience, since single pill treatments tend to be covered by patents on the combinations, even when the underlying drugs are off patent.
The best thing to do with CIC is convince them that she does not require treatment in the 5-10 year time frame under consideration.