No.. Not necessary. CIC needs to see if you have access to liquid funds that are unencumbered. If the source of funds that you are showing is from a loan (a personal loan for example) then there is possibility of rejection. However if the loan in question is something like a Home loan or car loan then I do not think it should lead to a rejection as there is also a corresponding asset that is linked to the loan.
I myself had a personal loan reflected in my account. I showed additional funds as savings that would leave me with enough funds to cross CICs requirements even if the personal loan amount is deducted. Yet to see if that works out in my favour.