Hello dearYes, you can update your profile before getting an ITA. If you have mentioned your spouse as "not accompanying" because you are not making a ITA cut-off score by accompanying her/him but somehow you have PNP now (which gets you good enough score), you can absolutely make those changes.
I am in similar condition
I got Ontario nomination in my profile with spouse non-accompanying
I got ita recently, and my score is 1050
Can i add my spouse now before submitting my file ? Have you added your spouse and recieved pr. Please reply !