All application go through the following:
R10
Medicals
Criminality
Eligibility
Security
1. If your application is incomplete, without explanation, it can be rejected for incompleteness at R10 See stages of an application
https://bit.ly/3v10OZm
2. If you or any family member (accompanying or not) in your application is inadmissible due to medicals, your application will be refused. See
https://bit.ly/3cxnr0w
3. If you or any family member (accompanying or not) in your application is inadmissible due to serious criminality, your application will be refused
4. During Eligibility, it is ascertained that what you claimed in your profile based on which you were issued an ITA, you have met that criteria by submitting the requested documents. The eligibility criteria if assessed, and is called A11.2. To read on how applications are assessed for A11.2 see
https://www.canada.ca/en/immigration-refugees-citizenship/corporate/publications-manuals/operational-bulletins-manuals/permanent-residence/express-entry/assessing-electronic-application-on-section-a11-2.html
Eligibility takes place in 2 stages, to read on this and how your GCMS notes will look, see my previous post at
#4,004
5. Finally, after eligibility is passed, it is ascertained that no family member is inadmissible sue to A35/37 of IRPA, i.e. security / human rights violations. To read on security and how it is done, see
https://bit.ly/3apWglN
At each stage, you have to meet a different criteria. As long a you meet them, it does not matter whether your spouse is accompanying or not, except when all family members declared in the application are evaluated for inadmissibility, specifically for medicals, criminality and security.
Hope this helps!