Baloo, I am not sure the OP is a spousal case. I am suspecting she wants to apply under FSW as a nurse.
Is that right, Lynn? You should try to get things done fast because there is a quota of 500 and it is already at 178 applications since July 1st. If your job description fits as a licensed practical nurse, you could apply under their quota. They are only up to 7 now, see http://www.cic.gc.ca/english/immigrate/skilled/complete-applications.asp
Otherwise, just follow the instructions at http://www.cic.gc.ca/english/immigrate/skilled/apply-how.asp and ask away if you have specific questions. What I found to be the most work for the application was putting together the job and address history since the age of 18.
You will also need a police clearance from all countries where you spent 6 months or more since age 18 and you will need to take IELTS to prove your English skills. Nothing against you, everybody has to take one these days.