Hi there,
I am in the same boat as you. I was told that I didn't need to decline my ITA, but rather wait till I officially finish 3 years and then submit. The CIC personnel will check your eligibility criteria either on the draw date or the date your submit everything officially (e-APR). You need to satisfy the three-year rule (or whatever experience you are claiming) in either of those. Some people say that this method is not right and that people need to decline ITA. In my personal opinion, I disagree with them because of the following:
https://www.canada.ca/en/immigration-refugees-citizenship/services/immigrate-canada/express-entry/submit-profile/respond-invitation.html
P.S: Thanks to @
Dheana90 for passing the info.
As you will have 60 days to submit the documentation, you could submit your documentation anytime after August 15th 2019, if you feel comfortable submitting after August 22nd 2019, please do so as well. Irrespective, I think it's in your best interests to write a cover letter explaining this as well as consulting with someone with legal experience. I am not an immigration expert or a lawyer, so please don't take my word as gospel.
As far as your second question, I think one week vacation doesn't really affect as the hours you have worked in the year should reach a minimum threshold of 1560 hours. This is roughly about 33 hours a week. I assume your US employer's work schedule is 40 hours a week, right? So I am sure you have over 1560 hours.
Since you are working for the same employer and same position I assume, I don't think you should worry much. However, just to be in the safer side ( assuming you are asked to give a separate work experience letter for this time period), its better to submit your e-APR after the completion of 3 year period ( August 22nd 2019 in your case). I cannot emphasize this enough, please consult with a legal entity ( not those fake consultants in India please) like a real immigration lawyer to get some additional clarification. You may spend a few hundred dollars on consultation, but it will definitely be worth the peace of mind.
As far as the medical exam goes, if you are young and healthy without any illness and if you are not taking any medications, you could get your medicals done either in the US or India. I prefer getting mine done in the US because I think we can get a copy of our report and I don't think that's possible in India ( fellow forum members feel free to correct me on this). Seeing the report say that everything is normal or within range gives some additional sense of comfort.
More info on medical exams:
https://www.canada.ca/en/immigration-refugees-citizenship/services/application/medical-police/medical-exams/requirements-permanent-residents.html